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HEINMGH KUIBTiI, 0F BASEL, TGNUht TU l' l ll CJEEEMICAL WORKS, Uh W YUIRJK, Til. 311, it. CUUTTOhi' 0T5 NEW ro rnocnss roe run w TACTUM 0h EASTLY-SULUBLTE CUTWIPUUNTW Uh TlEElEtG. G.-

specification of Letters Patent. Patented (adopt, tlfi, than, a l cation that an or, rare. serial No. errata To all whom it may concern:

Be it known that T, HEINRICH linear, a citizen of Switzerland, and a resident of Basel, Switzerland, have invented certain new and useful Improvements in Processes tor the Manufacture of Easily-Soluble Cour pounds of the G. C. Dialkylbarloituric Acids, of which the following is a specification.

My invention relates to a new method tor rendering the C. G-dialkylharbituric acids more easily soluble in water loy allowing alkylarnins to act upon them. The C. C.- dialkylharhituric acids, which are very much used as soporifics, are but dificultly soluble in cold water. Their aqueous solutions are therefore not suitable for injections and the like purposes. Tn consequence or this deficiency the demand for easily soluble, injectahle soporifics had to he covered with the sodium salts oil the O. G..- dialkylharhituric acids. These sodium salts are easily soluble in water, hut the strongly alkaline solutions cause decomposition of the harhituric acids and in consequence thereof the products soonlose a great deal of their activity. The compounds of U. U-dialkylloarhituric ac'ds and allrylarnins are crystallized hodies which dissolve easily in cold water and in alcohol especially when heated. Compared with the tree dialhylharhituric acids their hypnotic action is considerahly greater, and their aqueous solutions are a great deal more stable than those agulates. By exposing this compound ot dlethylharhituric acid and diethylamin tor a short time to the air it may from an excess or diethylamin. lit is very easlly soluble in water, easily soluble in alcohol especially when heated.

Ewamplc t.

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To 1 part oil phenylethylharhituric acid is added 1.5 parts of a 30 per cent. aqueous solution oil dimethylainin. Through the heat produced by the reaction a syru dike liquid is obtained from which, on 1 eing evaporated 27m. cacao, the compound oil phenylethylbarhituric acid and dimethylaniin crystallizes in large prisms. The compound dissolves easily in water.

Emample .t.

it part or diethylharhituric acid is added to 6 parts at an aqueous solution containing (it parts ct diethylaniin. The diethylhar loituric acid is completely dissolved and the resulting solution, whio The new products are to he used lt'or therapeutic purposes.

, Erornplc'l. it part oil very finely powdered diethyl harhituric acid is thoroughly stirred together with 0.55 parts oil diethylarnin. The heat produced causes the resulting mixture to dissolve into a clear syrup which soon co h according to circumstances may have to he filtered hetero hand, is ready to he used tor therapeutic purposes.

The new compoundsare to he loolred upon as salts of the G. U-dialhylloarhituric acids, Their tormnlas are the tollowinygz.

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5 211/ c0 NH (2) Diallylbaz-bituric- (Example 2) cam /C0-NH\. (c nema acid diethylamin (3) Phenylethylbarbituric aciddimethylamin (Example 3) C,H\ /CONH\. cHmNB: c o a I claim:

1. As a new article of manufacture the easily soluble compounds of the C. C.- dialkylbarbituric acids and alkylamins substantially as described. 2

2. The process for the manufacture of easily soluble compounds of the C. C.- dialkylbarbituric acids by allowing alkylamins to act upon the said acids.

In Witness whereof I have hereunto set 5 my hand.

- HEINRICH KUBLI. Witnesses:

JFE. BARELL,

EDUARD L. N ENK. 

